Intestinal Dysbiosis and Alopecia areata

Kornisheva V.G., Mogileva E.Yu., Voytova Е. V.

Alopecia areata is a multifactorial genetically determined disease. The foci of chronic infection are one of the factors causing the onset of the disease. Sustained intestinal dysbiosis contributes to the clinical manifestations of atopic and autoimmune syndromes.
The study of the microbiota of the intestine was performed 50 patients (main group - 44 patients with alopecia areata and the control group - 6 patients with seborrheic hair loss). The patients’ age was from 18 to 53 years (mean age 25.6 years).
Results. Dysbiosis grade 2-3 was diagnosed in 79.5% of patients with alopecia areata. Dysbiosis grade 2 was more than 4 times often in the progressive stage of disease than at patients in the regressive stage. The intestinal dysbiosis was combined with chronic infection foci in 62.5% of patients with alopecia areata. The growth of opportunistic pathogens (Enterococcus, Klebsiella, Candida, St. aureus, Ps. aeruginosa) was obtained in 94,3% of patients with alopecia areata, fungi of the genus Candida – in 31,4%. There was more frequent than in patients with seborrheic hair loss. Isolation of opportunistic pathogens with a reduced number of normobioty in intestines was characterized by the progressive stage of alopecia areata.
Conclusions. Intestinal dysbiosis supported the progression of alopecia areata.