English
Aims and scope Subscription Info for authors Editor-in-chief Editorial Board Contacts
International journal of Immunopathology, allergology, infectology.

Peculiarities of immune response in patients with COVID-19

Baranova N.I., Aschina L.A., Bolgova A.I.

PIUV a branch of the Federal State Budgetary Educational Institution of Higher Professional Education of the Russian Ministry of Health, Penza, Russia

Aim of the study: analysis of peculiarities of immune response in patients with COVID-19 in comparison with such in healthy subjects.
Methods. Subjects of the study were 96 patients with moderate and severe COVID-19 infection. Immunological analysis included chemiluminescence evaluation of phagocytic activity of cells, study of cytokines (IL-18, FNO-α, IL-4, IL-10, IFN-γ) in supernatants, subpopulations of T and B lymphocytes, functional activity of T lymphocytes.
Results. Immunological defects found in patients with COVID-19 in comparison with the control group were: an elevated level of leukocytes, neutrophils, monocytes and decrease of normalized maximum intensity of neutrophils luminescence (Imax). Prominent deviations in humoral immunity factors discovered were: an increased levels of IgA and IgG, reduced IgM; in the system of cytokines increased spontaneous and induced production of IL-18, decreased induced FNO-α, increased spontaneous IL-4. As for the immune T-system, we revealed a statistically significant decrease of functional and quantitative indices of T cells and CD3+CD8+ cytotoxic lymphocytes in the patients with COVID-19 compared to the control group.
Conclusion. The revealed immune defects in the systems of innate and adaptive immunity of patients with COVID-19 contribute to the understanding of immunopathogenesis of the disease and render the necessity of further research into the immune mechanisms of recovery after primary infection.

Keywords

Immunological markers, cytokines, immunopathogenesis, COVID-19, SARS-CoV-2

Fulltext in PDF

Open file
Size: 618 KB

DOI

10.14427/jipai.2023.3.41

Reference

Baranova N.I., Aschina L.A., Bolgova A.I. Immunopathology, allergology, infectology 2023; 3:41-45. DOI: 10.14427/jipai.2023.3.41