Disorders of iron metabolism in patients with juvenile idiopathic arthritis

Strogaya N.V., Ibragimova Zh.A., Kartun L.V., Chodosovskaja E.V.

Belarusian State Medical University, Minsk, Belarus

Juvenile idiopathic arthritis (JIA) is a chronic autoimmune inflammatory disease. One of the extra-articular manifestations of JIA is a violation of iron metabolism.

The aim of the study: to study the features of iron metabolism in patients with JIA.

Material and methods. We examined 65 patients with JIA at the age of 11 (6; 14) years. Indicators of iron metabolism (serum iron, ferritin, transferrin, unsaturated iron-binding capacity of serum and erythropoietin) were analyzed.

Results. Among patients with JIA, a decrease in the content of serum iron was found in 53.8% cases, in 4.6% patients there was an increase in the content of erythropoietin. The presence of the disease had a negative effect on iron content (H= 14.9) and was accompanied by an increase in the content of ferritin (H= 6.9) and erythropoietin (H= 24.3).

Conclusion. In JIA, there are no abnormalities of iron transport and the ability of serum to bind free iron, while JIA contributes to the intensity of erythropoiesis increase.