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International journal of Immunopathology, allergology, infectology.

Disorders of iron metabolism in patients with juvenile idiopathic arthritis

Strogaya N.V., Ibragimova Zh.A., Kartun L.V., Chodosovskaja E.V.

Belarusian State Medical University, Minsk, Belarus

Juvenile idiopathic arthritis (JIA) is a chronic autoimmune inflammatory disease. One of the extra-articular manifestations of JIA is a violation of iron metabolism.

The aim of the study: to study the features of iron metabolism in patients with JIA.

Material and methods. We examined 65 patients with JIA at the age of 11 (6; 14) years. Indicators of iron metabolism (serum iron, ferritin, transferrin, unsaturated iron-binding capacity of serum and erythropoietin) were analyzed.

Results. Among patients with JIA, a decrease in the content of serum iron was found in 53.8% cases, in 4.6% patients there was an increase in the content of erythropoietin. The presence of the disease had a negative effect on iron content (H= 14.9) and was accompanied by an increase in the content of ferritin (H= 6.9) and erythropoietin (H= 24.3).

Conclusion. In JIA, there are no abnormalities of iron transport and the ability of serum to bind free iron, while JIA contributes to the intensity of erythropoiesis increase.

Keywords

Juvenile idiopathic arthritis, iron, iron deficiency anemia, anemia of chronic diseases.

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DOI

10.14427/jipai.2023.2.69

Reference

Strogaya N.V., Ibragimova Zh.A., Kartun L.V., Chodosovskaja E.V. Immunopathology, allergology, infectology 2023; 2:69-72. DOI: 10.14427/jipai.2023.2.69