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International journal of Immunopathology, allergology, infectology.

Dynamics of liver function indicators in patients with COVID-19

Yupatov G.I., Pryshchepenko V.A., Okulich V.K., Denisenko N.V.

Vitebsk State Medical University, Vitebsk, Belarus

Aim of the study. To present the dynamics of transaminase levels in patients infected with the COVID-19 virus.

A retrospective analysis of case histories of 659 patients with COVID-19 infection was performed. The majority of patients with COVID-19 experienced changes in the complete blood count, such as leukocytosis, leukopenia, a shift in the leukocyte count, anemia, and changes in platelet levels. The level of hemoglobin, lymphocytes and monocytes was reduced, and the level of stab and segmented leukocytes, as well as ESR were increased in patients with severe COVID-19 who required oxygen therapy (p<0.05). Elevated transaminase levels in patients with COVID-19 are predominantly associated with severe infection. The need to prescribe massive drug therapy, including non-steroidal anti-inflammatory drugs, contributed to the development of toxic liver damage with a moderate impairment of its function. Restoration of transaminases in most patients required more than 20 days.


COVID-19, SARS-Cov-2, transaminases, AST, ALT.

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Yupatov G.I., Pryshchepenko V.A., Okulich V.K., Denisenko N.V. Immunopathology, allergology, infectology 2023; 2:56-60. DOI: 10.14427/jipai.2023.2.56