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International journal of Immunopathology, allergology, infectology.

Long-term data of interval hypoxic therapy in patient rehabilitation after COVID-19

Misirova I.A., Startseva S.V., Borukaeva I.Kh., Abazova Z.Kh., Kardanova L.D.

Kabardino-Balkarian State University named after HM. Berbekov, Nalchik
N.N. Burdenko Voronezh State Medical University, Ministry of Health Care of the Russian Federation, Voronezh

im. Studying the consistency of long-term results of normobaric interval hypoxytherapy in patients with moderate coronavirus infection COVID-19 3 months after the first course.

Materials and methods. The main group consisted of 85 patients who had moderately severe coronavirus infection and underwent 15 sessions of interval hypoxytherapy. The study included evaluations of functional respiratory system parameters, spirometric data, exhaled air condensate, prooxidant and antioxidant systems 3 months after the course of hypoxic therapy.

Results and discussion. As shown in the conducted studies, 3 months after the coronavirus infection the positive changes in the organs and systems revealed after 15 sessions of hypoxic therapy were preserved in the patients. The indices of the functional respiratory system in 3 months after hypoxic therapy remained at the same level, which indicated the absence of respiratory, circulatory, hemic and secondary tissue hypoxia in the patients. Preservation of low values of malondialdehyde in the blood and high values of superoxide dismutase and glutathione peroxidase activity led to a decrease in oxidative stress, mitigation of inflammation in organism, which was confirmed in changes in exhaled air condensate of patients after coronavirus infection COVID-19 (high volume of condensate, normalization of pH, decrease in lactate dehydrogenase, total proteins and lipids, surface tension of the condensate).

Conclusions. Normobaric interval hypoxytherapy may be used in patient rehabilitation after coronavirus infection and its positive effect is maintained for 3 months, so the repeated course of hypoxytherapy should be carried out not earlier than after 3 months.


COVID-19 coronavirus infection, normobaric interval hypoxic therapy, prooxidant and antioxidant systems.

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Misirova I.A., Startseva S.V., Borukaeva I.Kh., Abazova Z.Kh., Kardanova L.D. Immunopathology, allergology, infectology 2023; 1:87-92. DOI: 10.14427/jipai.2023.1.87