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International journal of Immunopathology, allergology, infectology.

Interleukin-10 in the differential diagnosis of bacteremia caused by gram-negative and gram-positive microorganisms in patients with sepsis

Abramovskikh O.S., Chetvernina E.A.

South Ural State Medical University of the Ministry of Healthcare of the Russian Federation, Chelyabinsk

The aim of the study was to assess the possibility of using indicators of IL-1β, IL-6, IL-8, IL-10, IL-18, TNF-α, PAD-4 and the functional activity of neutrophils in the differential diagnosis of bacteremia caused by gram-negative and gram-positive microorganisms in patients with sepsis.
Results. A case-control study was conducted on the basis of a cohort which included 48 patients with sepsis 30 of whom had a positive blood culture depending on the presence of gram-positive or gram-negative flora in the blood. They were divided into 2 groups. In patients of both groups in the blood on the 1st and 3rd day of the disease, the level of IL-1β, IL-6, IL-8, IL-10, IL-18, TNF-α, PAD4, NET and the functional activity of neutrophils were assessed, were determined. When comparing parameters between groups, IL-10 was higher in patients with gram-negative sepsis, and the ratio of IL-6/IL-10 was lower than in patients with gram-positive sepsis on day 1st of observation.

Keywords

Sepsis, cytokines, netosis, innate immunity, gram-negative and gram-positive sepsis, IL-10.

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DOI

10.14427/jipai.2022.4.47

Reference

Abramovskikh O.S., Chetvernina E.A. Immunopathology, allergology, infectology 2022; 4:47-55. DOI: 10.14427/jipai.2022.4.47