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International journal of Immunopathology, allergology, infectology.

Modern concept of pathogenesis of atopic diseases

Petrov S.Yu., Khlgatian S.V., Berzhets V.M., Radikova O.V.

Mechnikov Research Institute of Vaccines and Sera, Moscow, Russia

Atopic diseases take an important place among human diseases. Genetic predisposition to allergy and influence of environmental factors are the main causes of atopy. The pathogenesis of atopy is based on disorders of intracellular and intercellular regulation of the immune system. The main pathological shift is observed in the imbalance of regulatory effects between Th1, Th2 and Treg cells, with the predominance of Th2 effects. A lot of interesting modern knowledge about intercellular interactions of the immunological system in the formation of allergopathology is discussed in this review.


Allergens, Thymic stromal lymphopoietin, Transforming growth factor beta, atopy, T regulatory cells

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Petrov S.Yu., Khlgatian S.V., Berzhets V.M., Radikova O.V. Immunopathology, allergology, infectology 2019; 1:72-79. DOI: 10.14427/jipai.2019.1.72