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International journal of Immunopathology, allergology, infectology.

Immunoglobulin A (IgA): the structure, receptors of interaction, selective IgA deficiency

Shytikova M.G.

Belorussian Research Center for Pediatric Oncology, Hematology and Immunology

The immunoglobulin A (IgA) is the main immunoglobulin providing immune humoral reactions on the surface of mucous membranes. Violations of the structure, activity and/or mechanisms of regulation of IgA synthesis caused by genetic mutations or arising as a result of secondary immunodeficiency, most often lead to the development of an infectious syndrome with a tendency to chronic current the inflammatory process with frequent relapses. The manifestation of hypoglobulinemia A may also be autoimmune processes and/or allergic pathology in the form of various clinical syndromes. To date, clear diagnostic criteria, schemes of replacement therapy have been developed and the economic costs of pharmacological therapy of pathology associated with the violation of the synthesis of other major immunoglobulins have been analyzed, but the question of correction of the deficiency IgA remains open and needs further study.


Immunoglobulin A (IgA), secretory component (SC), pIgR, FcαRI/CD89, immunoglobulin deficiency.

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Shytikova M.G. Immunopathology, allergology, infectology 2019; 1:52-60. DOI: 10.14427/jipai.2019.1.52