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International journal of Immunopathology, allergology, infectology.

Comparative cytotoxic activity of mononuclear cells and neutrophils of peripheral blood during the threatened miscarriage

Tatarkova E.A., Tuguz A.R., Tsikunib A.A., Smolkov I.V., Shumilov D.S., Sakhtaryek Z.N.

1 Adyghe State University, Research Institute of Complex Problems, Immunogenetic Laboratory, Maikop, Russia
2 Maikop City Clinical Hospital, Obstetric Department of Pathology of Pregnancy No. 2 (small terms), Maikop, Russia
3 Maikop City Clinical Hospital, Medical Genetic Consultation of the Consultative and Diagnostic Polyclinic, Maikop, Russia

The formation of the fetoplacental complex during gestation is associated with the functional activity of neutrophilic granulocytes (NG) and peripheral blood mononuclear cells (PBMC) [1-5]. In MTT-assay, we investigated the cytotoxic activity (CTA) of NG and PBMC at women with the threat of termination of early pregnancy (n=28), pregnant without complications (n=7) and midgestation period (n=12). It was experimentally established that in women with clinically verified early reproductive complications CTA of neutrophils in vitro significantly (p≤0.05) increased compared to similar indicators in women with physiological pregnancy. High cytotoxic activity of neutrophils and mononuclear cells of peripheral blood is associated with early reproductive losses.


Cytotoxic activity, mononuclear cells, neutrophils, the threat of termination of early pregnancy, reproductive losses.




Tatarkova E.A., Tuguz A.R., Tsikunib A.A., Smolkov I.V., Shumilov D.S., Sakhtaryek Z.N. Immunopathology, allergology, infectology 2018; 2:40-47. DOI: 10.14427/jipai.2018.2.40