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International journal of Immunopathology, allergology, infectology.

An alternative approach to topical therapy of atopic dermatitis complicated by staphylococcal infection

ikhomirov ., Fedorova N., Baskakova I., ikhomirov ., Taganov .

1 Pirogov russian national research medical university
2 Russian Children's Clinical Hospital
3 Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Objective: to evaluate the clinical efficacy of topical forms of the microsilver drug in the complex therapy of atopic dermatitis complicated by staphylococcal infection.
Materials and methods: the patients (n=60) aged 217 years, suffering from atopic dermatitis average and heavy severity. When admitted to hospital, participants conducted bacteriological examination of the affected skin Species identification was carried out using analyzer Phoenix (USA). The participants were divided into the main group (n=30) and control group (n=30). The main group received topical therapy with microsilver drug 2 times a day for 7 days. The comparison group received traditional systemic, topical and physical therapy. On the 7th day control bacteriological examination was held. The clinical condition of patients before, during, and after treatment was assessed using the SCORAD index.
Results: bacteriological study of children of the main group determined the colonization of S. aureus affected skin of 30 (100%) patients, 11 (36.6%) high growth, 18 (60%) moderate, 1 (3?3%) low. While 26 (86.6%) participants of the comparison group were colonized by S. aureus, 13 (43?3%) of them had a high growth, 13 (43?3%) moderate. Data on the therapeutic efficacy of microsilver drugs (free of glucocorticosteroids and antibiotics) in comparison with traditional topical therapy were obtained. In the main and the comparison group there was a decrease in SCORAD
by 33,57% and 32,27%, respectively. The differences were statistically insignificant p=0,1924, (p>0,05). The control bacteriological study demonstrated in the main group a decrease in S. aureus colonization in 96.6% of children, in 23,3% S. aureus elimination was achieved. In the comparison group, the decrease of colonization of S. aureus was observed in 60% of patients, the elimination of S. aureus was not observed.


Atopic dermatitis, S. aureus, microsilver

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ikhomirov ., Fedorova N., Baskakova I., ikhomirov ., Taganov . Immunopathology, allergology, infectology 2018; 2:6-14. DOI: 10.14427/jipai.2018.2.6