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International journal of Immunopathology, allergology, infectology.

Quantitative and Functional Changes in the Indices of Lymphocytes in Women Blood at Different Periods of Ontogenesis

Frolova L.A., Frolov A.K.

Zaporizhzhia national university, Zaporizhzhia, Ukraine

Reproductive processes in the female body in all stages of ontogenesis are held with the active participation of the immune system. That is why the status of regulatory and effector lymphocyte populations changes at different periods of ontogenesis. The levels of immune cells at the reproductive period were at the physiological level. The ratio of helper and suppressor lymphocyte subsets is balanced; CD2 regulatory index (CD2 RI) (CD4/CD8 + CD16) tents to one. Neurohormonal alteration in women organism, during menopause is accompanied by activation of productive (helper) immune reactions in climacteric period by CD4 and CD25 lymphocytes’ subpopulations (CD2 RI of activated fraction = 1.26±0.26). Intense remodulating processes in climacteric period were on the suppressor background of lymphocytes’ activation by activating CD8, CD 16 subpopulations (CD2-RI = 0.74±0.06).


Women, ontogenesis, immunity, CDlymphocytes, regulatory index

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Frolova L.A., Frolov A.K. Immunopathology, allergology, infectology 2013; 1:20-25. DOI: 10.14427/jipai.2013.1.20