Character of distribution of immunological indicators in patients with average and severe forms of acne
Ryabova V.V., Koshkin S.V., Zaitseva G.À., Evseeva A.L.
Kirov State Medical University of the Ministry of Healthcare of the Russian Federation
Kirov Research Institute of Hematology and Blood Transfusion of the Federal Medical Biological Agency, Russian Federation
Purpose. To study the distribution of class I antigens in the general group and in the groups of patients allocated depending on the severity of the clinical picture of acne. To establish the presence of an associative association of severe forms of acne with the antigens of the Class I HLA complex. Materials and methods. The character of the distribution of class I HLA antigens was studied by a standard microlymphotoxic test in 56 patients with papulopustular and nodulocystic forms of acne.
Results. HLA-A3 and B35 antigens and intralocuss combinations of HLA A2-A3 and HLA A2-Ax can be regarded as protective immunogenetic markers, and combinations of HLA A2-B7, HLA A1-B17, HLA A2-B12 as papulopustular and nodulocystic forms of the disease.
Conclusion. The presence of an associative connection of severe and moderate forms of acne with the histocompatibility antigens of the Class I HLA complex has been identified, which allows to consider the clinical polymorphism of acne from the
perspective of endogenous determinism.