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International journal of Immunopathology, allergology, infectology.

Neuromimunnological mechanisms of pain syndrome development

Moseikin I.A., Levashova A.I., MyagkovaM.A.

1 Institute of Physiologically Active Substances of the Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
2 Russian Medical Academy of Postgraduate Education, Moscow

The purpose of this review is to generalize and analyze the results of studies of the mechanism of pain syndrome development, to evaluate the role of molecular receptors common for nervous and immunocompetent cells in the combined regulation of pain control systems and immune responses. The opiate nociception system refers to the basic structures of pain signal suppression. It includes opioids, usually short peptides, which are ligands of interaction with mu, kappa and delta receptors. Endogenous opioids provide a biochemical link between the brain, neuroendocrine and immune systems. Anti-opiate system maintains homeostatic control of antinociceptive effects of opiates. The questions of possible mechanisms of regulation of pain sensitivity and immunocompetence of the organism are considered.


Pain syndrome, opiate and anti-opiate system, molecular receptors, pain control systems and immune responses.

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Moseikin I.A., Levashova A.I., MyagkovaM.A. Immunopathology, allergology, infectology 2017; 1:6-15. DOI: 10.14427/jipai.2017.1.6