On the role of galectin-3 and interleukin-6 in immune responses of rosacea patients
Aripova M.L., Zima A.P., Vasil’eva O.A., Hardikova S.A.
Siberian State Medical University, Tomsk, Russia
Aim. Determining the level of galectin-3, IL-6 in the blood serum of patients with rosacea and rosacea in combination with chronic opisthorchiasis.
Subjects and methods. In the blood serum of 80 rosacea patients, 64 patients with rosacea, combined with chronic opisthorchiasis and 20 healthy donors were studied concentrations of galectin 3, IL-6 by ELISA.
Results. The concentration of galectin 3, IL-6 was significantly elevated in patients with rosacea, rosacea, combined with chronic opisthorchiasis as compared with the healthy controls. The positive correlation between the severity of clinical manifestations of rosacea and the level of galectin 3 (r = 0,72), IL-6 (r = 0,64) in the two groups.
Conclusion. The results indicate an imbalance content (galectin-3; IL-6) in serum of patients with rosacea, which can be seen as further evidence of the inferiority of the immune response in rosacea.