The evidence behind effective treatment of tinea infections with sertaconazole

Sergeev A.Y., Burtseva G.N., Nikolaevskiy V.O., Sergeev Yu.Yu.

I.M. Sechenov 1st MSMU, Moscow
All-Russian National Academy of Mycology

Dermatophyte infections, including tinea pedis et corporis, retain their position as a major problem of global dermatology. A significant effort is made to develop and produce better antifugals, including dozens of topical preparations. Newer molecules gradually replace first generation imidazoles and allylamines. Their comparison is a challenging task for researches and clinical trials. One of newer antifungal preparations is sertaconazole, the potent, fungicidal azole compound with broad antifungal spectrum of action and inherent anti-inflammatory properties. Accumulated evidence of its clinical use describes topical preparations of sertaconazole nitrate as highly effective in treatment of major forms of tinea infections. International clinical trials favor selection of newer topical forms of sertaconazole, developed in India. In particular, cream and solution containing 2% of sertaconazole nitrate may be recommended as economically effective choice for topical therapy of cutaneous fungal infections.