Association of apelin-12, adiponectin, leptin and resistin in allergic bronchial asthma evaluated with integral indices
Mineev V.N., Lalaeva T.M., Kuzmina A.A.
Pavlov’s First Saint-Petersburg State medical University, Saint-Petersburg, Russia
The aim of the study is to evaluate the expression of association of apelin-12, adiponectin, leptin and resistin with the use of integral indexes in allergic bronchial asthma (ABA).
Material and methods. 11 healthy controls, 29 patients with bronchial asthma were examined.
Plasma apelin-12, adiponectin, leptin and resistin levels were measured by enzyme immunoassay (ELISA). Modified indexes that include the integral levels of these 4 adipokines were worked out.
Results. The significant negative correlations of integral indexes values that include apelin and adiponectin expression with values of airways resistance (Raw) and with the content of peripheral blood mononuclear cells (lymphocytes and monocytes) and eosinophils respectively were revealed.
Conclusion. The suggestion of the particular specialization of the effects of adipokines in ABA was put forward: apelin signaling is involved mainly in the regulation of bronchial resistance and adiponectin signaling is involved mainly in the regulation of the inflammation cells activity.