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International journal of Immunopathology, allergology, infectology.

Reaction of patients’ lymphocytes’ blast-transformation in blood, stimulated by plant mitogens and annelid antigens at hirudotherapy

Frolov A.K., Litvinenko R.A.

Zaporizhzhia national university, Zhukovskogo str, 66 bld., Zaporizhzhia, 69600, Ukraine

Investigated the effects of plant mitogens and antigens from salt extraction of medicinal leeches (Hirudo verbana, H. medicinalis, H. orientalis) and red Californian worms (Eisenia fetida) on the reaction of peripheral lymphocytes’ blast-transformation in blood of healthy donors and patients before and after the course hirudotherapy. Demonstrated a difference action of three species leeches in healthy donors and patients. A course of hirudotherapy provides immunotropic effect on the human body that is manifested by increased potential lymphocyte proliferative capacity when tested in culture. Antigens of leeches and red Californian worms in the majority lead to apoptotic and necrotic responses of lymphocytes. The highest level of lymphocytes’ blast-transformation was detected in cultures with antigens of H. orientalis and Eisenia fetida, irrespective of hirudotherapy.


Reaction of lymphocyte blast-transformation, hirudotherapy, medicinal leech, antigens, mitogens

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Frolov A.K., Litvinenko R.A. Immunopathology, allergology, infectology 2014; 3:10-13