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International journal of Immunopathology, allergology, infectology.

Improvement of methods for allergen extracts standardization: from PNU to LC-MS

Bokov D.O., Smirnov V.V.

I.M. Sechenov First Moscow State Medical University

This article reviews the questions of production, standardization and application in Russia and abroad of diagnostic and therapeutic allergenic extracts used in allergen-specific immunotherapy (ASIT). Reports assessing the quality of biological products prepared according to regulatory documents using biological, immunochemical and modern physico-chemical methods (methods of in vitro and in vivo diagnostics) are considered. The procedure for full birch pollen extract standardization by liquid chromatography chromato-massspectrometry (LC-MS) developed on the basis of I.M. Sechenov First Moscow State Medical University is given as an example.


Allergen-specific immunotherapy, allergenic extracts, standardization, LC-MS.

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Bokov D.O., Smirnov V.V. Immunopathology, allergology, infectology 2013; 4:31-41. DOI: 10.14427/jipai.2013.4.31