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International journal of Immunopathology, allergology, infectology.

New approaches in theory of drug-induced hypersensitivity: from allergy to viral-dependent autoimmunity

Maltsev D., Kazmirchuk V., Tsarik V.

The last decade witnessed a revolutionary breakthrough in the study of the phenomenon of hypersensitivity to the drug (DIHS - drug-induced hypersensitivity syndrome, or DRESS Drug reaction with eosinophilia and systemic symptoms), previously considered solely as a kind of delayed-type allergic reaction. These reactions appear in the application of some antiepileptic (carbamazepine, lamotrigine, phenytoin, zonizamid), amitriptyline, allopurinol, mexiletine, sulfasalazine, some antibiotics (amoxicillin, ceftriaxone, karbapenemy), and others. Today convincingly demonstrated a close association between hypersensitivity reactions to drugs of endogenous reactivation herpesviruses (often - HHV-6, at least - HHV-7, EBV and CMV). To explain the relationship between hypersensitivity and viral reactivation involved in molecular mimicry theory, viral and synthetic theories, which discussed in this review.


Herpesviruses, hypersensitivity to the drug, molecular mimicry, autoimmune reactions.

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Maltsev D., Kazmirchuk V., Tsarik V. Immunopathology, allergology, infectology 2011; 3:87-100