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International journal of Immunopathology, allergology, infectology.

Immunodeficiency and antiphospholipid immunoglobulin for exacerbations of chronic obstructive pulmonary disease and bronchial asthma

Agapova Y.R., Gulin A.V., Malysheva E.V.

Lipetsk State Technical University

The content of serum gamma-globulin fraction (by electrophoresis on cellulose acetate) and antiphospholipid antibodies (by indirect enzyme linked immunosorbent assay - ELISA) in patients with acute exacerbation of COPD and bronchial asthma was studied. A reduction in percentages of gamma-fraction below normal was found in 35.7%, 60.7% and 75.0% of patients with COPD II, III, and IV, respectively, and 22.2% of patients with asthma (p <0, 01). The extent of deficits was 10.9%, 16.2, 20.0% and 34.8% in patients with COPD I, II, III, and IV, respectively (p <0.001) and 25.2% for heavy and prolonged / or frequent exacerbations of asthma. Excess antibodies to phospholipids found in 16.4% of patients with COPD and in 29.6% of patients with asthma (p <0.001). Autoantibodies in 2 times more frequent in patients with low gamma-globulins long experience disease with moderate to severe disease severity. It was recommended that the identification and correction of such shifts.


COPD, asthma, aggravation, gamma-globulin fraction, antibodies to phospholipids, serum.

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Agapova Y.R., Gulin A.V., Malysheva E.V. Immunopathology, allergology, infectology 2013; 3:27-35. DOI: 10.14427/jipai.2013.3.27